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Deracemization of racemic 1,2-diol by biocatalytic stereoinversion

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
10
Issue
21
Identifiers
DOI: 10.1016/s0957-4166(99)00452-8
Keywords
  • Article

Abstract

Abstract Deracemization of racemic 1,2-diol, ( RS)-1-{2′,3′-dihydrobenzo[ b]furan-4′-yl}-ethane-1,2-diol ( 1), by stereoinversion by several microorganisms belonging to the genera Candida and Pichia provided the corresponding chiral ( S)-diol, ( S)-1-{2′,3′-dihydrobenzo[ b]furan-4′-yl}-ethane-1,2-diol ( 2). ( S)-Diol 2 was obtained in yields of 60–70% with 90–100% enantiomeric excess.

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