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An improved synthesis of (−)-dodecahydro-3a,6,6,9a-tetramethylnaphthol[2,1-b]furan via ozonolysis of (−)-sclareol

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
35
Issue
51
Identifiers
DOI: 10.1016/0040-4039(94)88497-8

Abstract

Abstract Ozonolysis of (−)-sclareol 1 under a wide range of experimental conditions has been investigated. The addition of one of the following; sodium periodate, sodium iodate, iodine or potassium iodide affords after workup the methyl-ketone 2 in excellent yield. Further elaboration of 2 afforded the title compound 4 in high yield.

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