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Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions

Authors
Journal
Journal of Toxicologic Pathology
0914-9198
Publisher
The Japanese Society of Toxicologic Pathology
Publication Date
Volume
25
Issue
3
Identifiers
DOI: 10.1293/tox.25.189
Keywords
  • Review
Disciplines
  • Medicine

Abstract

In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

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