Affordable Access

Publisher Website

Scales of fish arise from mesoderm

Authors
Journal
Current Biology
0960-9822
Publisher
Elsevier
Publication Date
Volume
23
Issue
9
Identifiers
DOI: 10.1016/j.cub.2013.02.056
Disciplines
  • Medicine

Abstract

Summary The trunk of fish is covered by a large variety of morphologically and structurally diverse skeletal elements, such as scales, scutes and bony plates [1]. These elements are formed from intramembraneous ossifications and are part of the integumentary skeleton [2]. Histological and developmental similarities with neural crest-derived teeth in fossil and extant vertebrates, have led to the widely accepted notion that scales and fin rays, which are thought to be a scale modification, primarily derive from neural crest and not from mesodermal sources as the majority of the post-cranial skeleton [2]. Although short- and long-term labeling experiments in zebrafish have suggested a neural crest origin of fin rays [3,4], the contribution of neural crest to the post-cranial integumentary skeleton, and in particular to the scales, has not been thoroughly analyzed. By Cre/loxP-based genetic labeling, transplantation experiments and transposon-mediated clonal analysis, we demonstrate a mesodermal origin of scale-forming osteoblasts. Furthermore, our data do not support an extensive, if any, neural crest contribution to the post-cranial integumentary skeleton.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Low dimensional attractors arise from forcing at s...

on Physica D Nonlinear Phenomena Jan 01, 2003

Fish scales in sediments from off Callao, central...

on Deep Sea Research Part II Topi... Jan 01, 2009
More articles like this..