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Wilms' tumor in the neonate: A report from the national Wilms' tumor study

Authors
Journal
Journal of Pediatric Surgery
0022-3468
Publisher
Elsevier
Publication Date
Volume
21
Issue
5
Identifiers
DOI: 10.1016/s0022-3468(86)80502-4
Keywords
  • Wilms' Tumor
Disciplines
  • Biology
  • Medicine

Abstract

Renal neoplasms in the neonate are quite uncommon. Twentyseven of the 3,340 patients (0.8%) registered on the National Wilms' Tumor Studies from 1969 through April 1984, were 30 days old or less. Of these 27 patients, 18 had mesoblastic nephroma, 1 had a malignant rhabdoid tumor of the kidney, and 4 others had nonneoplastic lesions. The remaining four infants were reviewed in detail. All had favorable histology Wilms' tumors; none had distant metastasis at diagnosis. Treatment ranged from surgery alone to excision plus three-drug therapy for 15 months. All fared well. The patient with Stage I rhabdoid tumor died at eight weeks of age in spite of aggressive four-drug therapy. This review supports the view that Wilms' tumor in the neonate is extremely rare.

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