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Tirucallane triterpenes fromDysoxylum macranthum

Authors
Journal
Phytochemistry
0031-9422
Publisher
Elsevier
Publication Date
Volume
52
Issue
8
Identifiers
DOI: 10.1016/s0031-9422(99)00455-0
Keywords
  • Dysoxylum Macranthum
  • Meliaceae
  • Tirucallane Triterpenoids
  • Structural Elucidation

Abstract

Abstract Eleven new tirucallane-type triterpenes, dymacrins A–K, were isolated from the bark of Dysoxylum macranthum together with two known tetracyclic triterpenes and two known pregnane steroids. The structures of the new compounds were determined by spectral means, essentially 2D NMR experiments. Dymacrins B, C, H and J showed moderate cytotoxicity against KB cells (IC 50 5.6, 5.0, 8.3 and 1.0 μg/ml, respectively).

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