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Apomorphine-haloperidol interactions: Different types of antagonism in cortical and subcortical brain regions

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
205
Issue
2
Identifiers
DOI: 10.1016/0006-8993(81)90342-5
Keywords
  • Dopamine Metabolites
  • Apomorphine
  • Haloperidol
  • Frontal Cortex

Abstract

Abstract Apomorphine, a dopamine (DA) receptor stimulant induced a dose-dependent decrease in the content of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the olfactory tubercle and striatum of rats, but it was ineffective in the frontal cortex. Apomorphine also antagonized the haloperidol-induced accumulation of DOPAC and HVA in the olfactory tubercle and striatum, whereas in the frontal cortex it antagonized the effects of haloperidol on DOPAC but not on HVA. The total (free and conjugated) content of DA metabolites was measured in these experiments.

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