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Effect of cobalt on microsomal cytochrome P-450: Differences between liver and intestinal mucosa

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
65
Issue
4
Identifiers
DOI: 10.1016/s0006-291x(75)80382-2

Abstract

Summary Parenteral administration of cobalt to rats stimulated hepatic microsomal heme oxygenase (MHO) activity, depressed cytochrome P-450 content and reduced benzpyrene hydroxylase (BPH) activity, confirming previous reports. By contrast, in the intestinal mucosa, cobalt treatment not only stimulated MHO but in addition increased both cytochrome P-450 and BPH. This differential effect between liver and intestine suggests that the mechanism of the cobalt-mediated stimulation of MHO in the two tissues either differs and/or is unrelated to the turnover of cytochrome P-450.

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