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The synthesis of β-strand mimetic templates via regioselective 1,3-dipolar cycloaddition with vinylsulfone

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
42
Issue
7
Identifiers
DOI: 10.1016/s0040-4039(00)02229-2
Keywords
  • 1
  • 3-Dipolar Cycloaddition
  • Vinyl Sulfone
  • Peptidomimetics
  • Serine Protease Inhibitor

Abstract

Abstract We have developed a practical synthetic route to constrained β-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of β-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.

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