External Validation of Adjuvant! Online Breast Cancer Prognosis Tool. Prioritising Recommendations for Improvement

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External Validation of Adjuvant! Online Breast Cancer Prognosis Tool. Prioritising Recommendations for Improvement

Authors
Publisher
Public Library of Science
Volume
6
Issue
11
Identifiers
DOI: 10.1371/journal.pone.0027446
Keywords
  • Computer Science
  • Oncology
  • Biology
  • Computational Biology
  • Medicine
  • Computer Modeling
  • Research Article
  • Cancer Screening
  • Computer Applications
  • Cancers And Neoplasms
  • Cancer Detection And Diagnosis
  • Web-Based Applications
  • Breast Tumors
  • Mathematical Computing
  • Computing Methods

Abstract

Background Adjuvant! Online is a web-based application designed to provide 10 years survival probability of patients with breast cancer. Several predictors have not been assessed in the original Adjuvant! Online study. We provide the validation of Adjuvant! Online algorithm on two breast cancer datasets, and we determined whether the accuracy of Adjuvant! Online is improved with other well-known prognostic factors. Patients and Methods The French data set is composed of 456 women with early breast cancer. The Dutch data set is composed of 295 women less than 52 years of age. Agreement between observation and Adjuvant! Online prediction was checked, and logistic models were performed to estimate the prognostic information added by risk factors to Adjuvant! Online prediction. Results Adjuvant! Online prediction was overall well-calibrated in the French data set but failed in some subgroups of such high grade and HER2 positive patients. HER2 status, Mitotic Index and Ki67 added significant information to Adjuvant! Online prediction. In the Dutch data set, the overall 10-year survival was overestimated by Adjuvant! Online, particularly in patients less than 40 years old. Conclusion Adjuvant! Online needs to be updated to adjust overoptimistic results in young and high grade patients, and should consider new predictors such as Ki67, HER2 and Mitotic Index.

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