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Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats

Authors
Journal
Environmental Toxicology and Pharmacology
1382-6689
Publisher
Elsevier
Publication Date
Volume
31
Issue
3
Identifiers
DOI: 10.1016/j.etap.2011.01.006
Keywords
  • Toxicokinetics
  • Naringin
  • Naringenin
  • Rats
Disciplines
  • Medicine
  • Pharmacology

Abstract

Abstract The toxicokinetic characteristics of naringin were investigated in rats that had been orally administered naringin extract, a candidate for oral treatment of cough, prepared from Citrus grandis “Tomentosa”, at 50, 250, or 1250 mg/kg/day in a repeated-dose study for 1, 32, 93, or 184 days. Increased values of the mean systemic exposure were approximately proportional to increases in dose levels during all collection intervals; no saturation was observed. No significant differences in mean systemic exposure were observed between male and female rats. Results provide a reference for interpretation of toxicology findings and relevance to clinical safety issues.

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