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Regeneration of Vitamin A Deficient Rat Tracheal Epithelium After Mild Mechanical Injury:Growth Kinetics and Cellular Differentiation

Authors
Journal
Differentiation
0301-4681
Publisher
Elsevier
Publication Date
Volume
14
Identifiers
DOI: 10.1111/j.1432-0436.1979.tb01015.x
Keywords
  • Short Reports

Abstract

Mild mechanical abrasion of tracheal epithelium of Vitamin A deficient rats removed the superficial cells and spared basal cells which divided to repopulate the damaged area. The proliferative cells passed through a period of DNA synthesis with the greatest numbers of thymidine incorporating cells in samples labelled 22 h after injury. A peak of cell division occurred at 32 h and there was no further DNA synthesis or cell division. The area of wounding exhibited squamous metaplasia while normal pseudostratified muco-ciliary structure was retained by adjacent epithelium which had not been injured. The data indicates that squamous metaplasia in the respiratory epithelium in longstanding Vitamin A deficiency is due to redirected differentiation of basal cells and is seen only after mitotic activity has occurred.

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