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Microprocedure to determine the polymorphic forms of acid α1-glycoprotein in plasma:Application to depressive patients treated with amitriptyline

Authors
Journal
Journal of Chromatography B Biomedical Sciences and Applications
0378-4347
Publisher
Elsevier
Publication Date
Volume
229
Issue
2
Identifiers
DOI: 10.1016/s0378-4347(00)84274-7
Disciplines
  • Biology

Abstract

Abstract The polymorphic forms of α 1-acid glycoprotein have been determined by isoelectric focusing of small samples of whole plasma, without prior isolation of the protein. The results obtained by this technique confirm the microheterogeneity of this glycoprotein, which is not due to artefacts. Densitometric measurements of the polymorphic forms of this protein, which binds antidepressive drugs, have been performed in twelve depressive patients.

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