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Age and number of organ dysfunctions are associated with early mortality in patients suffering from severe sepsis treated with recombinant human activated protein C

Authors
Publisher
BioMed Central Ltd.
Publication Date
Disciplines
  • Medicine

Abstract

Available online http://ccforum.com/supplements/8/S1 Critical Care Volume 8 Suppl 1, 2004 24th International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium, 30 March – 2 April 2004 Published online: 15 March 2004 These abstracts are online at http://ccforum.com/supplements/8/S1 © 2004 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) P1 The conditioning of medical gases with hot water humidifiers D Chiumello, M Cressoni, C De Grandis, L Landi, M Racagni Policlinico IRCCS, Milano, Italy Critical Care 2004, 8(Suppl 1):P1 (DOI 10.1186/cc2468) During invasive mechanical ventilation due to the dryness of medical gases is necessary to provide an adequate level of conditioning. The hot water humidifiers (HWH) heat the water, thus allowing the water vapor to heat and humidify the medical gases. In the common HWH there is a contact between the medical gases and the sterile water, thus increasing the risk of patient’s colonization and infection. Recently to avoid the condensation in the inspiratory limb of the ventilator circuit, new heated ventilator circuits have been developed. In this in vitro study we evaluated the efficiency (absolute/relative humidity) of three HWH: (1) a common HWH without a heated ventilator circuit (MR 730, Fisher&Paykel, New Zeland), (2) the same HWH with a heated ventilator circuit (Mallinckrodt Dar, Italy) and (3) a new HWH (DAR HC 2000, Mallinkckrodt Dar, Italy) with a heated ventilator circuit in which the water vapor reaches the medical gases through a gorotex membrane, avoiding any direct contact between the water and gases. At a temperature of 35°C and 37°C the HWH and heated tube were evaluated. The absolute humidity (AH) and relative humidity (RH) were measured by a psychometric method. The minute ventilation, tidal volume respiratory rate and oxygen fraction were: 5.8 ± 0.1 l/min, 740 ± 258 ml, 7.5 ± 2.6 bpm and 100%, respectively. Ventilator settings were maintained constant for all the study period. The measurements

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