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Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma

Authors
Journal
OncoImmunology
2162-4011
Publisher
Landes Bioscience
Publication Date
Volume
1
Issue
6
Identifiers
DOI: 10.4161/onci.19789
Keywords
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Abstract

To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal transition and angiogenesis.1

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