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Cyclic adenosine monophosphate-phosphodiesterase activity in cultured keratinocytes from patients with atopic eczema

Authors
Journal
Journal of Dermatological Science
0923-1811
Publisher
Elsevier
Publication Date
Volume
2
Issue
4
Identifiers
DOI: 10.1016/0923-1811(91)90049-4
Keywords
  • Cyclic Adenosine Monophosphate-Phosphodiesterase
  • Atopic Dermatitis
  • Cultured Kerationcytes
Disciplines
  • Biology

Abstract

Abstract A number of previous studies have documented an increase in cyclic adenosine monophosphate-phosphodiesterase activity in patients with atopic dermatitis. We have studied the activity of this enzyme in keratinocytes cultured from patients with atopic dermatitis compared to keratinocytes from non-atopic controls. Results show that these pure preparations of keratinocytes express only one form of cyclic adenosine monophosphate phosphodiesterase with a K m of 1.9 μM, and a V max of 17 pmol/min/mg of substrate converted. We conclude that cyclic adenosine monophosphate-phosphodiesterase activity in cultured keratinocytes from patients with atopic eczema does not differ from controls.

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