Background To assess the validity of estrogen receptor (ER) status of breast tumor as a prognostic marker in clinical practice in the Indian perspective. Materials and methods Sixty-three patients of breast cancer attending breast clinic IPGMER, Kolkata were included in this study. All patients underwent surgery. Metastatic status and tumor were done. Immunohistochemistry was also used for further analysis. Results Statistically we have proved that advancing course of the disease, there is a tendency of the tumors to become hormone insensitive. Conclusions ER has a strong prognostic importance in early breast cancer and can play a major role in optimizing treatment modalities in node negative early breast cancer.