Affordable Access

Publisher Website

Chapter 7 Gene expression associated with muscle adaptation in response to physical signals

Authors
Identifiers
DOI: 10.1016/s1568-1254(01)80009-7
Disciplines
  • Chemistry
  • Design

Abstract

Publisher Summary Muscle provides several striking examples of the way a tissue can adapt to different types of physical signals. Adaptation to a different work regime is brought about by changes in fiber type and cross-sectional area, which result in altered fatigue resistance and power output. This process involves quantitative and qualitative changes in gene expression including the myosin heavy chain isogenes, which encode different types of molecular motors. Using a similar process some species of fish respond to seasonal temperate change and are able to rebuild their myofibrillar systems for warm and cold temperature swimming by selective myosin gene expression. In mammals, it is apparent that muscle tissue is influenced by mechanical signals and that there must be local as well as systemic regulation of tissue mass and phenotype. The nature of the chemical link between the physical signal and the up-regulation of certain muscle genes involved in muscle mass determination has been elucidated by the cloning of a new growth factor that is only expressed in muscles subjected to stretch and/or exercise and that is designed for an autocrine/paracrine action.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Physical activity, muscle, and the HSP70 response.

on Canadian journal of applied ph... June 1998

Gene expression profiles in response to the activa...

on Clinical and Experimental Phar... September 2004

Mechanical signals, IGF-I gene splicing, and muscl...

on Physiology (Bethesda, Md.) August 2005

[Adaptation to physical exertion increases express...

on Biulleten' eksperimental'noĭ... July 1999
More articles like this..