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An endemic neurological disorder in tribal Australian aborigines.

Authors
Journal
Journal of Neurology Neurosurgery & Psychiatry
0022-3050
Publisher
BMJ
Publication Date
Keywords
  • Research Article
Disciplines
  • Medicine

Abstract

Thirteen, and possibly sixteen cases of neurological disorder have been identified in a population of approximately 1100 tribal aborigines living in Groote Eylandt and the adjacent mainland. There were two relatively distinct clinical pictures: one coming on in childhood involved the motor system, the patients often having remarkably lax ligaments; and the other, generally of later onset, comprising cerebellar, upper motor neurone and sometimes supranuclear ophthalmoplegic features. There was some evidence that the two syndromes are varieties of a single condition. No causal factors were identified but there were indications that the disorder might be genetically determined. Attention is drawn to the similarities between this disorder and other ethnic-geographic isolates, particularly the ALS-Parkinsonism-dementia complex of Guam. Images

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