Affordable Access

Publisher Website

Models of the impact of dengue vaccines: A review of current research and potential approaches

Authors
Journal
Vaccine
0264-410X
Publisher
Elsevier
Publication Date
Volume
29
Issue
35
Identifiers
DOI: 10.1016/j.vaccine.2011.06.042
Keywords
  • Dengue
  • Vaccine
  • Theoretical Model
  • Review
Disciplines
  • Mathematics

Abstract

Abstract Vaccination reduces transmission of pathogens directly, by preventing individual infections, and indirectly, by reducing the probability of contact between infected individuals and susceptible ones. The potential combined impact of future dengue vaccines can be estimated using mathematical models of transmission. However, there is considerable uncertainty in the structure of models that accurately represent dengue transmission dynamics. Here, we review models that could be used to assess the impact of future dengue immunization programmes. We also review approaches that have been used to validate and parameterize models. A key parameter of all approaches is the basic reproduction number, R 0, which can be used to determine the critical vaccination fraction to eliminate transmission. We review several methods that have been used to estimate this quantity. Finally, we discuss the characteristics of dengue vaccines that must be estimated to accurately assess their potential impact on dengue virus transmission.

There are no comments yet on this publication. Be the first to share your thoughts.