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Processing of reactor-produced188W for fabrication of clinical scale alumina-based188W/188Re generators

Authors
Journal
Applied Radiation and Isotopes
0969-8043
Publisher
Elsevier
Publication Date
Volume
45
Issue
12
Identifiers
DOI: 10.1016/0969-8043(94)90026-4

Abstract

Abstract The traditional technique for processing of reactor-irradiated 186W-enriched tungsten oxide (WO 3) targets involves formation of 188W-sodium tungstate solutions by target dissolution in 0.1 M NaOH. Following long irradiations (> 21 days) in the ORNL High Flux Isotope Reactor (HFIR) the 186WO 3 targets contain a NaOH-insoluble 188W-labeled black solid (approx. 30–50% of total activity) which decreases the yield and specific activity of the processed 188W (e.g. 5–6 mCi/mg 186W for a 79-day irradiation). The black material is postulated to represent a “tungsten blue” insoluble polymeric form of tungsten oxide, which we have now found to dissolve in 0.1 M NaOH containing 5% sodium hypochlorite solution. Complete dissolution results in a significant increase in the yield and specific activity of sodium 188W-tungstate. As an alternative approach, irradiated 186W-enriched metal targets dissolve in sodium hydroxide solution by cautious addition of < 30% hydrogen peroxide. Sodium 188W-tungstate solutions prepared from processing of such metal targets show no evidence of residual black insoluble material. Specific activity values for completely dissolved HFIR-irradiated 186W targets have increased to 10 mCi/mg (43.5 days) and 12.9 mCi/mg (49.2 days). Large clinical scale (> 1 Ci) generators prepared from hypochlorite-processed 186W oxide or peroxide-processed 186W metal targets exhibit the expected 188Re high yield and low 188W breakthrough.

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