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Effect of new biologically active polypeptides on dihexadecyl phosphate vesicles

Authors
Journal
Pharmacological Research Communications
0031-6989
Publisher
Elsevier
Publication Date
Volume
19
Issue
7
Identifiers
DOI: 10.1016/0031-6989(87)90108-1
Keywords
  • Dihexadecylphosphate
  • Vesicles
  • Chemotactic Peptides
  • Permeation
  • Dhp
  • Dihexadecyl Phosphate
  • (Ru(Bpy)32+
  • Tris (2
  • 2′-Bipyridyl) Ruthenium (Ii) Chloride Hexahydrate
  • F-Mlp
  • N-Formyl L-Methionyl-L-Leucyl-L-Phenylalanine
  • Tboc
  • Terbutoxycarbonyl
  • Dmf
  • N
  • N-Dimethylformamide
Disciplines
  • Biology

Abstract

Abstract Effect of new biologically active polypeptides on hexadecyl phosphate vesicles. The effect that monomeric and trimeric chemotactic peptides may have on the permeation of DHP vesicles was studied by means of electronic absorption spectroscopy. The results show that attaching covalently two or more of the same chemotactic peptides to a suitable carrier molecule produced changes in the permeation of DHP vesicles that deviate from simple additivity rule. Thus a parallelism between the biological potency of the peptides and DHP permeation exists.

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