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Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats

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Scientific Research Publishing, Inc.
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Disciplines
  • Biology
  • Medicine

Abstract

Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats Journal of Behavioral and Brain Science, 2013, 3, 306-314 http://dx.doi.org/10.4236/jbbs.2013.33030 Published Online July 2013 (http://www.scirp.org/journal/jbbs) Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats Lise Skøtt Gregersen1, Turid Røsland1, Lars Arendt-Nielsen1, Garth Whiteside2, Michele Hummel2 1Center for Sensory-Motor Interaction, Aalborg University, Aalborg Ø, Denmark 2Purdue Pharma LP, Cranbury, USA Email: [email protected], [email protected], [email protected], [email protected], [email protected] Received March 20, 2013; revised April 25, 2013; accepted May 6, 2013 Copyright © 2013 Lise Skøtt Gregersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Novel preclinical models for prediction of osteoarthritis-like pain are necessary for the elucidation of osteoarthritis (OA) pathology and for assessment of novel analgesics. A widely used behavioral test in rat models of tibiofemoral OA is hind limb weight bearing (WB). However, this method evaluates WB in an unnaturally restricted manner. The aim of this study was therefore to characterize the Tekscan Pressure Measurement System as a means to assess OA-like tibiofemoral pain in rats by determination of plantar pressure distribution in a more natural and unre- stricted position, defined as unrestricted WB. Methods: Intra-articular injections of 1 mg monosodium iodoacetate (MIA) or saline were administrated in the left hind knee of 84 male Sprague Dawley rats. Changes in unrestricted WB between ipsilateral and contralateral hindlimbs were determined. Morphine (5

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