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Clinicopathologic Characteristics of T-cell Non-Hodgkin's Lymphoma: A Single Institution Experience

Authors
Journal
The Korean Journal of Internal Medicine
1226-3303
Publisher
Korean Association of Internal Medicine
Publication Date
Volume
24
Issue
2
Identifiers
DOI: 10.3904/kjim.2009.24.2.128
Keywords
  • Original Article
Disciplines
  • Biology
  • Medicine

Abstract

Background/Aims Although the incidence of T-cell non-Hodgkin's lymphoma (NHL) is higher in Far East Asia than in Western countries, its incidence and clinical course in Korea are not well-defined. Therefore, we assessed the relative frequency and clinical features of T-cell NHL in Korea. Methods We performed a retrospetcive analysis of 586 patients with NHL. Results 101 (17.2%) had T-cell NHL. The most frequent subtypes of T-cell NHL were extranodal NK/T-cell lymphoma, nasal type (NASAL), peripheral T-cell lymphoma, unspecified type (PTCL-U), and anaplastic large cell lymphoma, T/null cell, primary systemic type (ALCL). The seven pathological subtypes could be classified into three prognostic subgroups. When patients with the three most frequent subtypes were grouped together, their survival was reflected in the International Prognostic Index (IPI) scores. Univariate analysis of IPI elements and other clinical features showed that clinical stage and extranodal sites were significant predictors of survival. Cox multivariate analysis showed that the number of extranodal sites was the only independent prognostic indicator. Conclusions The relative frequency of T-cell NHL seems to be decreasing in Korea, although NASAL remains frequent. Korean patients with ALCL appear to have an unfavorable prognosis. Large-scale studies are warranted for Korean patients with T-cell NHL.

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