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Synthesis of Chiral Piperazinones as Versatile Scaffolds for Peptidomimetics

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
56
Issue
43
Identifiers
DOI: 10.1016/s0040-4020(00)00787-0
Keywords
  • Piperazinones
  • Peptide Mimetics
  • Biologically Active Compounds
  • Amino Sugars

Abstract

Abstract Chiral piperazinones were synthesized as conformationally restricted peptidomimetics starting from inexpensive and readily available d-glucosamine hydrochloride and amino acid methyl esters. Different synthetic strategies are devised to allow attachment of side chains imitating the parent peptide as shown for the RGD motif.

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