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Role of descending monoaminergic neurons in the control o sexual behavior: Effects of intrathecal infusions of 6-hydroxydopamine and 5,7-dihydroxytryptamine

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
268
Issue
2
Identifiers
DOI: 10.1016/0006-8993(83)90494-8
Keywords
  • Monoaminergic Neurons
  • Sexual Behavior
  • 6-Ohda
  • 5
  • 7-Dihydroxytryptamine

Abstract

Abstract The present study concerns the possible participation of descending monoamine pathways in the control of sexual behavior. Male and female rats received micro-injections of the neurotoxins, 6-hydroxydopamine (6-OHDA) or 5,7-dihydroxytryptamine (5,7-DHT), in the spinal subarachnoid space, which were found to deplete spinal synaptosomal uptake of radiolabeled noradrenaline and serotonin to 46.7% and 34.5%, respectively. Whereas intrathecal 5,7-DHT did not affect sexual behavior appreciably, female 6-OHDA-treated rats showed less sexual receptivity and proceptivity when exposed to constant estradiol; similarly treated males had prolonged post-ejaculatory refractory periods and were more sensitive than controls to androgen deprivation.

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