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Genetics (molecular biology) and Meniere's disease

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  • Medicine

Abstract

There is strong evidence of a genetic predisposition to Meniere's disease (MD) especially in a subset of some 7% showing an autosomal dominant inheritance with 60% penetrance of the gene(s), evidence of anticipation and an association with migraine and with the HLA antigens. The conclusions are based on 46 famiies with 118 memebers affected by classical MD in two or more generations. Linkage analysis has demonstrated a likely mutation close to the COCH gene on chromosome 14, but sequencing has excluded a pathogenic code change in any of the 12 exons of COCH. Both sporadic and familial MD are liekly to be heterogenetic and several candidate genes demand study.

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