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Effects of monoamine oxidase a inhibition on plasma biogenic amine metabolites in depressed patients

Authors
Journal
Psychiatry Research
0165-1781
Publisher
Elsevier
Publication Date
Volume
52
Issue
3
Identifiers
DOI: 10.1016/0165-1781(94)90071-x
Keywords
  • Affective Disorder
  • Moclobemide
  • 3-Methoxy-4-Hydroxyphenylglycol
  • Homovanillic Acid
  • 5-Hydroxyindoleacetic Acid

Abstract

Abstract The main metabolites of nonadrenalin, dopamine, and serotonin—3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), respectively—were estimated in plasma of 21 depressed patients before and after 2 and 4 weeks of treatment with the monamine oxidase-type A (MAO-A) inhibitor moclobemide (mean final daily dose = 8.9 mg/kg body weight). The treatment caused significant mean reductions in plasma MHPG and HVA (46% and 30%, respectively), while plasma 5-HIAA was unchanged. Multiple regression analysis revealed associations between reductions in MHPG and changes on the anxiety-somatization factor of the Hamilton Rating Scale for Depression (HRSD), and between reductions in HVA and changes in the HRSD factors cognitive disturbance and retardation.

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