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Retinal Degenerations: Genetics, Mechanisms, and Therapies

Authors
Journal
Journal of Ophthalmology
2090-004X
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
2011
Identifiers
DOI: 10.1155/2011/764873
Keywords
  • Editorial
Disciplines
  • Biology
  • Medicine

Abstract

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2011, Article ID 764873, 2 pages doi:10.1155/2011/764873 Editorial Retinal Degenerations: Genetics, Mechanisms, and Therapies Ian M. MacDonald,1 Muna I. Naash,2 and Radha Ayyagari3 1Department of Ophthalmology, University of Alberta, Royal Alexandra Hospital, 10240 Kingsway Avenue Room 2319, Edmonton, AB, Canada T5H 3V9 2Department of Cell Biology, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Boulevard, Oklahoma City, OK 73104, USA 3Shiley Eye Center, University of California San Diego, 9415 Campus Point Drive, Room 206, La Jolla, CA 92093, USA Correspondence should be addressed to Radha Ayyagari, [email protected] Received 17 July 2011; Accepted 17 July 2011 Copyright © 2011 Ian M. MacDonald et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The cumulative results from genetic research and treatment protocols tested on cell and animal models have improved our understanding of pathobiology of inherited and degen- erative eye diseases, and have lead to the development of a broad range of potential strategies to treat these conditions. In this special issue of the Journal of Ophthalmology, a series of articles provide a review of various areas of current eye research and clinical practice. A retinal degeneration phenotype is observed in several nonsyndromic and syndromic disorders, which are genet- ically and phenotypically heterogeneous. Usher syndrome, the commonest cause of deaf-blindness, is characterized by retinal degeneration, hearing loss, and, in some cases, abnormal vestibular function. Usher syndrome has been classified into three forms based on the age of onset, severity of retinal degeneration, and hearing loss. So far, nine genes associated with Usher syndrome have been identified. In this issue

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