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Relevance of animal models to human tardive dyskinesia

Authors
Journal
Behavioral and Brain Functions
1744-9081
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
8
Issue
1
Identifiers
DOI: 10.1186/1744-9081-8-12
Source
Legacy
Keywords
  • Review
Disciplines
  • Medicine

Abstract

Tardive dyskinesia remains an elusive and significant clinical entity that can possibly be understood via experimentation with animal models. We conducted a literature review on tardive dyskinesia modeling. Subchronic antipsychotic drug exposure is a standard approach to model tardive dyskinesia in rodents. Vacuous chewing movements constitute the most common pattern of expression of purposeless oral movements and represent an impermanent response, with individual and strain susceptibility differences. Transgenic mice are also used to address the contribution of adaptive and maladaptive signals induced during antipsychotic drug exposure. An emphasis on non-human primate modeling is proposed, and past experimental observations reviewed in various monkey species. Rodent and primate models are complementary, but the non-human primate model appears more convincingly similar to the human condition and better suited to address therapeutic issues against tardive dyskinesia.

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