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Zinc-mediated acylation and sulfonation of pyrrole and its derivatives

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
43
Issue
45
Identifiers
DOI: 10.1016/s0040-4039(02)01914-7
Keywords
  • Organozinc Reagents
  • C-Acylation
  • Sulfonylation
  • Pyrrole
  • 2-Substituted Pyrrole

Abstract

Abstract Pyrrole and its derivatives react smoothly with acid chlorides and sulfonyl chlorides in the presence of zinc metal in toluene at ambient temperature to afford the corresponding 2-acetyl and 2-sulfonyl pyrrole derivatives in high yields with high regioselectivity.

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