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Clastic cells: Mineralized tissue resorption in health and disease

Authors
Journal
The International Journal of Biochemistry & Cell Biology
1357-2725
Publisher
Elsevier
Publication Date
Volume
41
Issue
3
Identifiers
DOI: 10.1016/j.biocel.2008.09.007
Keywords
  • Clastic Cells
  • Osteoclast
  • Odontoclast
  • Resorption
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Clastic cells are responsible for mineralized tissue resorption. Bone resorbing cells are called osteoclasts; however, they are able to resorb mineralized dental tissues or calcified cartilage and then they are called odontoclasts and chondroclasts, respectively. They derive from mononuclear precursors of the monocyte–macrophage lineage from hemopoietic tissue, reach target mineralized tissues and degrade them under many different physiologic or pathologic stimuli. Clastic cells play a key role in calcium homeostasis, and participate in skeletal growth, tooth movement, and other physiological and pathological events. They interact tightly with forming cells in bone and dental hard tissues; their unbalance may result in disturbed resorptive activity thus, causing local or systemic diseases.

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