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Synergistic activation of the central pattern generator for locomotion byl-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
358
Issue
2
Identifiers
DOI: 10.1016/j.neulet.2003.12.120
Keywords
  • Rodent
  • Spinal
  • Cpg
  • Air-Stepping
  • Locomotion
  • 5-Ht
  • Noradrenergic

Abstract

Abstract l-beta-3,4-Dihydroxyphenylalanine ( l-DOPA) and quipazine, respectively dopamine/noradrenaline precursor and serotonergic (5-HT 2) receptor agonist, were injected intraperitoneally in low-thoracic spinal mice at 7 days post-spinalization. In mice pre-treated with decarboxylase and monoamine oxydase inhibitors, l-DOPA (30–100 mg/kg) was found not to induce air-stepping. On the other hand, l-DOPA (40 mg/kg) consistently triggered locomotor-like movements if combined with low doses of quipazine (0.4–0.7 mg/kg) or if mice were placed on a motor-driven treadmill running at low speed. However, twitches, spasms, and other non-locomotor movements were also induced, especially on the treadmill. These results suggest that (1) spinal catecholaminergic and serotonergic receptors interact synergistically to generate locomotor-like movements in chronic spinal mice, and that (2) hindlimb afferent inputs associated with the treadmill conditions contribute to the genesis of locomotor-like and non-locomotor movements induced by these drugs.

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