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Postsynaptic actin and neuronal plasticity

Authors
Journal
Current Opinion in Neurobiology
0959-4388
Publisher
Elsevier
Publication Date
Volume
9
Issue
5
Identifiers
DOI: 10.1016/s0959-4388(99)00018-5
Keywords
  • Plasticity
  • Synapse Morphology
  • Dendritic Spine
  • Cytoskeleton
  • Actin
  • Dendrite
Disciplines
  • Biology

Abstract

Abstract In the adult brain, actin is concentrated in dendritic spines where it can produce rapid changes in their shape. Through various synaptic junction proteins, this postsynaptic actin is linked to neurotransmitter receptors, influencing their function and, in turn, being influenced by them. Thus, the actin cytoskeleton is emerging as a key mediator between signal transmission and anatomical plasticity at excitatory synapses.

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