Affordable Access

1-Dimensional nanoparticles – A brief critical review on biological, medical, and toxicological aspects

Authors
Journal
Applied Surface Science
0169-4332
Publisher
Elsevier
Publication Date
Volume
275
Identifiers
DOI: 10.1016/j.apsusc.2013.01.122
Keywords
  • One Dimensional Materials
  • Nanomaterials
  • Carbon Nanotubes
  • Toxicology
  • Biological And Medical Aspects
  • Asbestos
  • Amyloids
  • Partial Phagocytosis
Disciplines
  • Biology

Abstract

Graphical abstract A critical review of the toxicity of one dimensional nanomaterials, with emphasize on carbon nanotubes is presented. The review focuses on the role of the size, aspect ratio, and mechanical properties on the toxicity of nanotubes and dissects the effect of the large lifetime of carbon nanotubes within cells and organisms. The figure provides a graphical representation of the three modes that describe the interaction between nanotubes and biological cells (in this case blood cells). The top panel describes the safe mode SM), the middle panel is representing the fakir mode (FM), and the bottom mode the impale mode (IM). To the left of each mode is shown qualitatively the stress (σ)–strain (ɛ) dependence for the cellular membrane with a localization of the mechanical domain associated to each mode. Highlights ► Reviews critically the toxicity and the risks of one dimensional nanomaterials. ► Investigates models/concepts about the toxicity of one dimensional nanomaterials. ► Discusses the connection between toxicity and carbon nanotubes retention. ► Reveals the combined effect of aspect ratio and mechanical properties. ► Suggests the role of partial phagocytosis.

There are no comments yet on this publication. Be the first to share your thoughts.