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Gen(om)e duplications in the evolution of early vertebrates

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1016/s0959-437x(96)80026-8

Abstract

Abstract Phylogenetic analyses and sequence surveys of developmental regulator gene families indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism. Neutral changes dominated at first but then positively selected regulatory changes evolved the novel and increasingly complex vertebrate developmental program.

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