In vitro–in vivo correlations for endocrine activity of a mixture of 5 currently used pesticides

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In vitro–in vivo correlations for endocrine activity of a mixture of 5 currently used pesticides

Elsevier Ireland Ltd
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  • Respectively
  • However
  • Overall
  • Nonetheless
  • Propiconazole
  • <P>Two Pesticide Mixtures Consisting Of Three And Five Currently Used Pesticides
  • Were Investigated For Potential Endocrine Disrupting Effects
  • Mix 3 Consisted Of Bitertanol
  • And Cypermethrin And Mix 5 Contained The Same 3 Pesticides Plus Malathion And Terbuthylazine
  • </P> <P>All Five Single Pesticides And The Two Mixtures Were Tested <Em>In Vitro</Em> In H295R Cells
  • All Five Pesticides Individually And Both Mixtures Affected Steroidogenesis
  • The Mixtures Caused An Increase In Progesterone And A Decrease In Testosterone
  • And Mix 5 Also Increased Estradiol
  • Indicating Increased Aromatase Activity
  • </P> <P>The Pesticide-Mixtures Were Also Investigated <Em>In Vivo</Em> In Pregnant Rats Dosed From G
  • Followed By Examination Of Dams And Fetuses
  • All 5 Pesticides Could Be Detected In The Amniotic Fluid
  • Demonstrating Exposure Of The Fetuses
  • Decreased Estradiol And Increased T4 Levels Were Seen In Dams Exposed To Mix 5
  • Neither Of The Two Mixtures Showed Any Effects On Fetal Hormone Levels
  • But Mix 5 Did Caused A Significant Increase In Aromatase Mrna Levels In Adrenal Glands From Female F
  • Aromatase Induction In Adrenals Was Found For Mix 5 Both In Vitro And <Em>In Vivo</Em>
  • The Hormonal Responses <Em>In Vitro</Em> Were Only Partly Reflected <Em>In Vivo</Em>
  • Probably Due To Adme Interactions
  • As The Amniotic Pesticide Levels Were Negatively Affected By The Number Of Compounds Present In The
  • The H295R Assay Gives Hints On Interference With Steroidogenesis
  • And It Is Suggested That One Underlying Mechanism For These Pesticides Is Disturbance Of Steroidogen


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