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Distinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoA carboxylase in liver

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
413
Issue
1
Identifiers
DOI: 10.1016/s0014-5793(97)00890-9
Keywords
  • Acetyl-Coa Carboxylase
  • Amp-Activated Protein Kinase
  • Glutamine
  • Hmgcoa Reductase
  • Protein Phosphatase-2A
Disciplines
  • Biology

Abstract

Abstract Acetyl-CoA carboxylase and HMGCoA reductase are inactivated by the same AMP-activated protein kinase and are activated by type-2A protein phosphatase. To determine whether the same species of protein phosphatase-2A were involved, we studied the interconversion of acetyl-CoA carboxylase and HMGCoA reductase in isolated rat hepatocytes. We show that (i) these enzymes are differently regulated in hepatocytes and (ii) the species of type-2A protein phosphatase involved in their activation are different and can be separated by anion-exchange chromatography.

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