Affordable Access

Publisher Website

Tailoring DNA Vaccines: Designing Strategies Against HER2-Positive Cancers

Frontiers in Oncology
Frontiers Media SA
Publication Date
DOI: 10.3389/fonc.2013.00122
  • Oncology
  • Mini Review
  • Biology
  • Design
  • Medicine


The crucial role of HER2 in epithelial transformation and its selective overexpression on cancer tissues makes it an ideal target for cancer immunotherapies such as passive immunotherapy with Trastuzumab. There are, however, a number of concerns regarding the use of monoclonal antibodies which include resistance, repeated treatments, considerable costs, and side effects that make active immunotherapies against HER2 desirable alternative approaches. The efficacy of anti-HER2 DNA vaccination has been widely demonstrated in transgenic cancer-prone mice, which recapitulate several features of human breast cancers. Nonetheless, the rational design of a cancer vaccine able to trigger a long-lasting immunity, and thus prevent tumor recurrence in patients, would require the understanding of how tolerance and immunosuppression regulate antitumor immune responses and, at the same time, the identification of the most immunogenic portions of the target protein. We herein retrace the findings that led to our most promising DNA vaccines that, by encoding human/rat chimeric forms of HER2, are able to circumvent peripheral tolerance. Preclinical data obtained with these chimeric DNA vaccines have provided the rationale for their use in an ongoing Phase I clinical trial (EudraCT 2011-001104-34).

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Designing HER2 vaccines.

on Seminars in Oncology June 2002

Designing HER2 vaccines

on Seminars in Oncology Jan 01, 2002

DNA vaccines: designing strategies against parasit...

on Genetic Vaccines and Therapy Jan 01, 2004
More articles like this..