Affordable Access

Publisher Website

A glycoprotein from a folk medicinal plant,Withania somnifera, inhibits hyaluronidase activity of snake venoms

Authors
Journal
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
1532-0456
Publisher
Elsevier
Publication Date
Volume
143
Issue
2
Identifiers
DOI: 10.1016/j.cbpc.2006.01.006
Keywords
  • Withania Somnifera
  • Snake Venom
  • Hyaluronidase
  • Hyaluronidase Inhibitor
  • Glycoprotein
  • N. Naja
  • D. Russelii
  • Extracellular Matrix
Disciplines
  • Biology

Abstract

Abstract Venom hyaluronidases help in rapid spreading of the toxins by destroying the integrity of the extra-cellular matrix of the tissues in the victims. A hyaluronidase inhibitor (WSG) is purified from a folk medicinal plant, Withania somnifera. The glycoprotein inhibited the hyaluronidase activity of cobra ( Naja naja) and viper ( Daboia russelii) venoms, which was demonstrated by zymogram assay and staining of the skin tissues for differential activity. WSG completely inhibited the activity of the enzyme at a concentration of 1 : 1 w / w of venom to WSG. Thus we are able to demonstrate that the glycoprotein inhibits hyaluronidase activity of the venoms. External application of the plant extract as an antidote in rural parts of India to snakebite victims appears to have a scientific basis.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

A glycoprotein from a folk medicinal plant, Withan...

on Comparative biochemistry and p... June 2006

Withaferin A: a new radiosensitizer from the India...

on International journal of radia... February 1996

Regeneration of plants from alginate-encapsulated...

on Journal of Plant Physiology February 2006

Germination behaviour of seeds of Withania somnife...

on Physiology and molecular biolo... July 2013
More articles like this..