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Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
108
Issue
3
Identifiers
DOI: 10.1016/0304-3940(90)90651-o
Keywords
  • N- Methyl- D-Aspartatereceptor
  • Allosteric Glycine Site
  • D-Serine
  • 7-Chlorokynurenate
  • Long-Term Potentiation
  • Hippocampus

Abstract

Abstract The effects of 7-chlorokynurenate (7-C1KY) were examined on N- methyl- d-aspartate (NMDA) receptor-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices. 7-C1KY depressed both the NMDA receptor-mediated component of synaptic transmission recorded in Mg 2+-free medium and the induction of long-term potentiation (LTP) in Mg 2+-containing medium. Both of these effects were reversed by d-serine, suggesting that the action of 7-C1KY was at the allosteric glycine site on the NMDA receptor.

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