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Antioxidation of human low density lipoprotein by horin hydrate

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
57
Issue
3
Identifiers
DOI: 10.1016/0024-3205(95)00274-a
Keywords
  • Low Density Lipoproteine Oxidation
  • Morin
  • Atherosclerosis
Disciplines
  • Biology

Abstract

Abstract Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at 100 μM concentration, effectively inhibits Cu 2+- induced oxidation of LDL. The oxidation of LDL was assessed by agarose gel electrophoresis. This was further studied by measuring the increased values of the malondialdehyde equivalents and the decreased numbers of reactive amino groups on oxidized LDL. Trolox, at equimolar concentrations, exhibit similar effects in preventing oxidation of LDL.

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