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AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis11 Accession no. for rat AATF nucleotide sequence at the EMBL GenBank database is RNO238717.

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
462
Identifiers
DOI: 10.1016/s0014-5793(99)01529-x
Keywords
  • Dlk/Zip Kinase
  • Two-Hybrid Screen
  • Transcription Factor
  • Acidic Domain
  • Apoptosis
  • Par-4
Disciplines
  • Biology

Abstract

Abstract Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb mRNA seems to be ubiquitously expressed. AATF contains an extremely acidic domain and a putative leucine zipper characteristic of transcription factors. Indeed, a Gal4-BD-AATF fusion protein exhibited strong transactivation activity. Interestingly, AATF interfered with Dlk-induced apoptosis.

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