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Loss of an adrenergic effect in swiss mice

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
38
Issue
2
Identifiers
DOI: 10.1016/0014-2999(76)90342-3
Keywords
  • β-Adrenergic Responsiveness
  • Hyperglycemia
  • Eosinophilia
  • Adrenergic Sensitivity
  • Biochemical Variation
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract The effect of adrenaline on the amount of blood eosinophils (eosinophilia) which had been found in Swiss mice in earlier experiments was lost after a few generations. The hyperglycermic response to adrenaline had not been changed. Sensitivities to noradrenaline and adrenaline were as found earlier, but the sensitivity to isoprenaline was reduced. The reduction of β-adrenergic responsiveness suggests variations in biochemical parameters of mice or the appearance of mice genetically less responsive to β-adrenergic drugs in only a few generations.

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