Affordable Access

Publisher Website

Antiepileptic effects of Clobazam in children

Brain and Development
DOI: 10.1016/s0387-7604(82)80102-2
  • Clobazam
  • Epilepsy
  • Serum Level


Many benzodiazepines used as anticonvulsants have nitrogen radicals in positions 1 and 4. Clobazam has nitrogen radicals in positions 1 and 5. We studied the antiepileptic effect of clobazam in 36 patients with intractable epilepsies in childhood. Their ages were 1 year 1 month to 16 years 5 months (mean 8 years). The mean initial dose was 0.33 mg/kg of daily doses and increased up to 0. 71 mg/kg. Nine cases (primary generalized epilepsy 2/2, secondary generalized epilepsy 7/29) were completely free from seizures, and another 9 (secondary generalized epilepsy 8/29, partial epilepsy 1/5) experienced a decrease of 50% or more in seizure frequency. Seizure frequency did not change in 16, and increased in the other 2 (secondary generalized epilepsy 2/29). The antiepileptic effects were observed on the first day to 10th day after clobazam treatment. There were recurrences of seizures in 4 out of 9 patients with complete control of seizures, 1 month later in 3 and 10 months later in one. Mean serum clobazam level of 7 improved cases was 73 ng/ml and that of 3 cases with no response was 94 ng/ml. Although mild clinical side effects such as drowsiness were observed transiently in 17 cases, no abnormality was found in laboratory investigations performed.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Interactions of clobazam with conventional antiepi...

on Journal of Child Neurology April 1997

Effects of age and antiepileptic drugs on plasma l...

on Pharmacology & toxicology August 1990

Side effects of antiepileptic drugs in children.

on Bratislavské lekárske listy December 1991
More articles like this..