The spatial distribution of sea bed covers and seagrass in coastal waters is of key importance in monitoring and managing Mediterranean shallow water environments often subject to both increasing anthropogenic impacts and climate change effects. In this context we present a methodology for effective monitoring and mapping of Posidonia oceanica (PO) meadows in turbid waters using remote sensing techniques tested by means of LAI (Leaf Area Index) point sea truth measurements. Preliminary results using Daedalus airborne sensor are reported referring to the PO meadows at Civitavecchia site (central Tyrrhenian sea) where vessel traffic due to presence of important harbors and huge power plant represent strong impact factors. This coastal area, 100 km far from Rome (Central Italy), is characterized also by significant hydrodynamic variations and other anthropogenic factors that affect the health of seagrass meadows with frequent turbidity and suspended sediments in the water column. During 2011–2012 years point measurements of several parameters related to PO meadows phenology were acquired on various stations distributed along 20 km of coast between the Civitavecchia and S. Marinella sites. The Daedalus airborne sensor multispectral data were preprocessed with the support of satellite (MERIS) derived water quality parameters to obtain here improved thematic maps of the local PO distribution. Their thematic accuracy was then evaluated as agreement (R2) with the point sea truth measurements and regressive modeling using an on purpose developd method.