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P55. Differentiated umbilical cord mesenchymal stem cells as a therapeutic resource

Authors
Journal
Differentiation
0301-4681
Publisher
Elsevier
Publication Date
Volume
80
Identifiers
DOI: 10.1016/j.diff.2010.09.061
Disciplines
  • Chemistry
  • Medicine

Abstract

In our present study, human umbilical cord mesenchymal stem cells (UCMSCs) were utilized for their immaturity. Expression of differentiated UCMSCs (dif-UCMSCs) makers was confirmed with RT-PCR, immunocytochemical assay. The dif-UCMSCs were transplanted into the chronic damaged mice livers. The secreted ALB in the damaged mice was as increased as non-damaged mice after dif-UCMSCs injection, while the mice with non- dif-UCMSCs were not recovered. Our results suggested that dif-UCMSCs were able to recover liver function of damaged mice. UCMSCs-derived differentiated cell transplantation could be promising alternative way of therapeutic option for liver failure.

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