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Comparison of focal macular cone ERGs in complete-type congenital stationary night blindness and APB-treated monkeys

Authors
Journal
Vision Research
0042-6989
Publisher
Elsevier
Publication Date
Volume
48
Issue
2
Identifiers
DOI: 10.1016/j.visres.2007.11.010
Keywords
  • Electroretinogram (Erg)
  • Focal Macular Cone Erg
  • Congenital Stationary Night Blindness (Csnb)
  • Complete-Type
  • Apb (L-2 Amino-4-Phosphonobutyric Acid)

Abstract

Abstract Focal macular cone electroretinograms (ERGs) and multifocal ERGs were recorded to study the macular function in patients with the complete-type of congenital stationary night blindness (cCSNB). The waveforms of the focal macular cone ERGs and the on- and off-responses of the multifocal ERGs in the cCSNB patients were similar to those recorded from monkey retinas treated with L-2 amino-4-phosphonobutyric acid (APB), suggesting that patients with cCSNB have a complete defect of the on-pathway even in the central retina. The results also demonstrated that there was a paradoxical positive response in the central retina of cCSNB patients, as compared to the negative full-field ERGs in the same subjects.

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