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Human erythrocyte transketolase: no evidence for variants

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
162
Issue
2
Identifiers
DOI: 10.1016/0009-8981(87)90453-0
Keywords
  • Erythrocyte Transketolase
  • Isoenzyme
  • Isoelectric Focusing
  • Wernicke-Korsakoff Syndrome
Disciplines
  • Biology

Abstract

Abstract Using isoelectric focusing of human erythrocyte transketolase, the isoenzyme pattern described recently ( Kaczmarek and Nixon, 1983) was reexamined. Seven bands having p I values of 7.4–8.4 were common to the central part of the transketolase isoenzyme pattern in 63 healthy subjects investigated and were definitely reproduced, whereas four additional marginal bands (p I values of 7.2, 7.3, 8.6 and 8.8) were found with varying intensities in part of the samples and could not always be reproduced. We conclude that the method used does not permit the distinction of transketolase variants, that would allow to postulate a genetic polymorphism, based only on variation of the marginal bands of the pattern.

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