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MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma

Authors
Publisher
BioMed Central
Publication Date
Volume
30
Issue
1
Identifiers
DOI: 10.1186/1756-9966-30-73
Keywords
  • Research
Disciplines
  • Medicine

Abstract

MiR-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. However the underlying mechanism of miR-106b involved in laryngeal carcinoma remains elusive. Here we showed that reduction of miR-106b induced cell cycle G0/G1 arrest by targeting tumor suppressor RB in human laryngeal carcinoma cells. Further, Introducing RB cDNA without 3'UTR abrogated miR-106b-induced cell proliferation. Finally, there was an inverse relationship between RB and miR-106b expression in laryngeal carcinoma tissues. To our knowledge, these data indicate for the first time that miR-106b directly regulate cell cycle by targeting RB in laryngeal carcinoma and that miR-106b could be potential therapeutic approaches for laryngeal carcinoma.

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